In the past I used a Javascript and CSS minifier in Visual Studio that I built on top of the original YUI compressor.  I implemented it via a Custom Tool / Single File Generator.  I figured this might be helpful with minifying the output of TypeScript.  I wanted to eliminate the Java dependency however, so  I built the generator on top of YUI Compressor.NET.  Unfortunately, this doesn’t seem to work for my situation.  When TypeScript generates new Javascript output it doesn’t seem to trigger the SFG to do its thing.   In any case I put the source on Github for anyone who is interested.